Looking to lead a stronger, healthier life?
Sign up for our Wellness Wire newsletter for all sorts of nutrition, fitness, and wellness wisdom.

Now we’re in this together.
Thanks for subscribing and having us along on your health and wellness journey.

See all Healthline's newsletters »
Content created by Healthline and sponsored by our partners. For more details click here.
Content sponsored by our partners. More details »

This content is created by the Healthline editorial team and is funded by a third party sponsor. The content is objective, medically accurate, and adheres to Healthline's editorial standards and policies. The content is not directed, edited, approved, or otherwise influenced by the advertisers represented on this page, with exception of the potential recommendation of the broad topic area.

Read more about Healthline's advertising and sponsorship policy.

Major Depressive Disorder

Major depressive disorder, also known as clinical depression or MDD, is a form of depression marked by extreme periods of sadness. About of American adults experience an episode of MDD each year.

Many of the symptoms of MDD are mental, including feeling restless and worthless. It can also take a physical toll on your body, leaving you tired and affecting your appetite and weight. While the cause of MDD is unknown, it can be treated through medications, lifestyle changes, and therapy.