Probiotics are a hot topic at the moment, particularly for people with irritable bowel syndrome (IBS).
IBS is a chronic disease that causes abdominal pain and changes in bowel habits.
Many people take probiotics in hopes that balancing out their gut bacteria will improve their symptoms.
This article looks at the latest research on probiotics for IBS, including specific strains and symptoms.
Irritable bowel syndrome is a chronic disease characterized by abdominal pain or discomfort, as well as bloating, gas, constipation and diarrhea ().
It affects 7–21% of people worldwide and is three times more prevalent in women than men in the West, though the difference is not as great in Asia (, , ).
The exact causes of IBS are unknown. However, some suggested causes include changes in digestive motility, infections, brain-gut interactions, bacterial overgrowth, food sensitivities, carbohydrate malabsorption and intestinal inflammation (, ).
Eating certain foods can trigger symptoms, and stress can worsen them (, ).
IBS is diagnosed when you have abdominal pain at least one day per week for three months, plus at least two of the following symptoms: pain related to a bowel movement, a change in stool frequency or a change in stool appearance ().
In addition, there are four subtypes of IBS, which relate to the type of bowel movement most often experienced ():
- IBS-D: Diarrhea-predominant
- IBS-C: Constipation-predominant
- IBS-M: Alternating between diarrhea and constipation
- IBS-U: Unspecified, for people who do not fit into one of the above categories
Another subtype, known as “post-infectious” IBS has also been suggested for people who develop the disease following an infection. This subtype may apply to as many as 25% of people with IBS ().
Treatment for all subtypes includes medication, diet and lifestyle improvements, the elimination of FODMAPs and lactose and the use of probiotics ().
FODMAPs are poorly digested types of carbohydrate molecules found naturally in many foods. They can cause gastrointestinal symptoms like gas and bloating, which can exacerbate IBS.
Summary Irritable bowel syndrome (IBS) is a chronic disease characterized by abdominal pain and changes in bowel movements. Its causes are not yet understood but may relate to brain-gut interactions, bacterial overgrowth, infection, inflammation and sensitivity.
Your digestive system is teeming with beneficial bacteria known as gut flora, and they play a critical role in your health (, ).
However, for various reasons the gut flora can sometimes get thrown out of balance, allowing harmful bacteria to proliferate ().
Probiotics are live bacteria or yeast found in foods and supplements. They’re safe, similar to natural gut flora and provide health benefits ().
People use them to promote a healthy, balanced gut flora. They may provide a number of health benefits, such as supporting weight loss, improving heart health, improving digestion and boosting the immune system (, ).
Some common probiotic foods include yogurt, sauerkraut, tempeh, kimchi and other fermented foods.
Additionally, common probiotic strains found in supplements include Lactobacillus and Bifidobacterium ().
Summary Probiotics are live bacteria and yeasts that people can consume to support and help balance the natural bacteria in the body. Common sources include yogurt, fermented foods and supplements.
A significant amount of recent research has investigated how probiotics might be used to treat and manage IBS.
IBS symptoms have been linked to certain changes in the gut flora. For example, people with IBS have lower amounts of Lactobacillus and Bifidobacterium in their guts, and higher levels of harmful Streptococcus, E. coli and Clostridium (, ).
Additionally, up to 84% of IBS patients experience bacterial overgrowth in their small intestines, which can lead to many of their symptoms ().
However, whether this change is a cause or result of IBS is uncertain. Also, certain medications used to treat symptoms of IBS can damage the healthy bacteria living in the gut (, ).
Changes in the gut flora may influence IBS symptoms by increasing inflammation, increasing sensitivity to gas in the intestine, reducing immune function and changing digestive motility (, ).
Probiotics have been proposed to improve symptoms by ():
- Inhibiting the growth of disease-causing bacteria
- Enhancing the immune system’s barrier functions
- Helping fight inflammation
- Slowing down bowel movements
- Reducing gas production by balancing the gut flora
- Reducing the gut’s sensitivity to gas buildup
However, not all probiotics are alike. In fact, the term “probiotic” covers many different strains and types of bacteria and yeasts. Their health effects vary depending on the type.
Summary Gut flora imbalances may contribute to the symptoms of IBS. Probiotics help restore balance in a number of ways, including by inhibiting the growth of harmful bacteria, reducing inflammation and slowing down the digestive system.
A comprehensive 2016 review concluded that it’s unclear how effective probiotics are for treating IBS. It cited small study sizes and lack of consistent data ().
However, a number of studies have shown that specific probiotics may have the potential to target specific symptoms. Probiotics from the Bifidobacterium, Lactobacillus and Saccharomyces families have shown particular promise (, ).
Overall Symptom Improvement
In a review by the British Dietetic Association (BDA), 29 studies assessed overall symptom improvements, and 14 of these showed a positive result for 10 different probiotics ().
For example, a study treated 214 IBS patients with the probiotic L. plantarum 299v. After four weeks, 78% of the patients scored the probiotic as good or excellent for improving symptoms, particularly for pain and bloating ().
These findings were supported by another study in Poland. However, two other smaller studies on the same probiotic strain did not find a positive effect (, , ).
A German study of a two-strain probiotic liquid known as Pro-Symbioflor also had promising results. In this study, 297 patients were treated for eight weeks and experienced a 50% decrease in general symptoms, including abdominal pain ().
Meanwhile, Symprove is a four-strain probiotic that was tested in 186 patients in the UK. It was found to reduce overall symptom severity after 12 weeks of treatment ().
Bifidobacterium infantis 35624 capsules have also been shown to marginally reduce pain, bloating and problems with bowel habits in all subtypes of IBS ().
While some of these results are promising, there is some inconsistency between studies. In addition, most strains only have one study demonstrating their effectiveness. Therefore, more research is needed to confirm the results.
Summary Preliminary research has found 10 probiotic strains that may help improve overall symptoms of IBS. However, results have been inconsistent, and most strains have only one small study behind them. Further research is required.
Abdominal pain is one of the key symptoms of IBS. It is often found in the lower or whole abdomen and subsides after a bowel movement ().
Seven types of probiotics have been associated with improvements in abdominal pain symptoms ().
The strain L. plantarum was found to decrease both the frequency and severity of abdominal pain, compared to a placebo ().
One study investigated the yeast S. cerevisiae, also known as Lesaffre. After eight weeks of treatment, 63% of people in the test group and 47% of people in the placebo group reported significant reductions in pain ().
In another study, participants drank a probiotic solution consisting of B. bifidum, B. lactis, L. acidophilus and L. casei for eight weeks. Their pain was reduced by 64% in the probiotics group and 38% in the placebo group ().
While this research is positive, the majority of studies on probiotics have not found a beneficial effect on pain. More studies are needed to confirm the findings for these strains.
It is also interesting to note how much impact the placebo effect seemed to have in these studies. The placebo effect is when people experience a positive effect during a study even when they are just taking a placebo. This is commonly observed in IBS research ().
Summary Abdominal pain is the primary symptom of IBS. Seven probiotic strains have been found to help reduce pain. However, more research is needed to confirm the results.
Bloating and Gas
Excess gas production and increased sensitivity can cause uncomfortable bloating and gas in IBS ().
In the 2016 BDA review, only two studies found that probiotics specifically reduced bloating, and only one found they reduced gas ().
The strain L. plantarum was found to decrease the frequency and severity of bloating symptoms, compared to a placebo ().
Another study treated patients with a rose-hip drink mixed with an oatmeal soup fermented with L. plantarum. The test group experienced significant reductions in gas, and both the test and placebo groups experienced reductions in abdominal pain ().
An additional study found that participants with IBS experienced reduced abdominal bloating after four weeks of treatment with a four-strain supplement containing B. lactis, L. acidophilus, L. bulgaricus and S. thermophilus ().
If excess gas and bloating is your primary problem with IBS, then one of these probiotics may improve your symptoms. However, further studies are needed.
Summary The strain L. plantarum has been found to reduce both abdominal bloating and gas. Another mixed-strain supplement has also resulted in reductions in gas. However, overall, few studies have shown that probiotics improve gas and bloating.
Approximately 15% of people with IBS experience the diarrhea-predominant form ().
While there has been a lot of research on probiotics for infection-related diarrhea, less is known about the effects of probiotics on non-infectious types, as in IBS.
One probiotic known as Bacillus coagulans has been found to improve multiple symptoms, including diarrhea and stool frequency. However, studies to date have only been small, so more research is needed (, ).
The probiotic yeast Saccharomyces boulardii has also been investigated for the treatment of diarrhea-predominant IBS. However, while one study found it improved bowel habits and decreased inflammation, another found no improvements (, ).
A multi-strain probiotic known as VSL#3 was tested in people with IBS and found to slow down the bowels and reduce gas. However, in a study specifically on people with diarrhea-predominant IBS, it was not found to improve bowel movements (, ).
Another multi-strain probiotic called Duolac 7 was tested in 50 patients over eight weeks. It was found to improve stool consistency significantly, compared to the placebo group, and there was a general improvement in symptoms ().
Overall, it appears that use of probiotics to treat diarrhea in IBS is not very effective, as only a few small-scale studies have shown improvements.
Summary While probiotic use for treatment of infectious diarrhea is well documented, there is less evidence for use in IBS diarrhea. B. coagulans and S. boulardii, as well as some multi-strain preparations, may have a positive effect, but more studies are needed.
The most common form of IBS is the constipation-predominant type, affecting nearly half of all people with the disease ().
Studies on constipation-predominant IBS have sought to determine if probiotics can increase the frequency of bowel movements and alleviate associated symptoms.
One study gave participants one of two multi-strain probiotics, one containing L. acidophilus and L. reuteri and the other containing L. plantarum, L. rhamnosus and L. lactis.
Treatment with these probiotics resulted in more frequent bowel movements and an improvement in consistency ().
In a study on children with IBS, treatment with the probiotic B. lactis and prebiotic inulin reduced constipation, bloating and feelings of fullness. However, it should be noted that in some patients with IBS, inulin may worsen symptoms (, ).
Additionally, S. cerevisiae has been found to reduce pain and bloating symptoms for constipation-predominant IBS. However, further studies are needed to confirm this ().
As with most of the other symptoms discussed, while some of these results are promising, studies to date have been small. There has not been enough research to confirm whether probiotics truly benefit people with constipation in IBS.
Summary Constipation-predominant IBS is the most common form of the disease. B. lactis, S. cerevisiae and some multi-strain probiotics have demonstrated positive effects. However, further studies are needed.
Despite some promising research, it is too early to make general recommendations about the use of probiotics for IBS.
While some strains have been shown to have benefits for one or two symptoms, the majority of probiotics are unlikely to cause improvements.
However, probiotics are safe, and a relatively cheap potential treatment option for IBS. Also, they have worked for some people, particularly for those with specific symptoms.
If you are interested in trying a probiotic, there is an .
Here are some key tips when making your selection:
- Choose an evidence-based probiotic: Select a probiotic that has research supporting it
- Select a probiotic according to your symptoms: Choose strains that work for your issues
- Take the right dose: Use the dosage recommended by the manufacturer
- Stick with one type: Try one variety for at least four weeks and monitor your symptoms
Keep in mind that some probiotic supplements contain ingredients that could make your symptoms worse. These include oats, inulin, lactose, fructose, sorbitol and xylitol. If your symptoms are triggered by any of these, look for a probiotic that does not contain them.
By taking the time to select a probiotic that best suits your needs, you may find they are an effective supplementary treatment for your IBS symptoms.
Even if you don’t experience significant improvements, probiotics still offer other great health benefits and can be a valuable component of a healthy lifestyle.
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